Aberrant activity in retinal degeneration impairs central visual processing and relies on Cx36-containing gap junctions
نویسندگان
چکیده
منابع مشابه
Block of gap junctions eliminates aberrant activity and restores light responses during retinal degeneration.
Retinal degeneration leads to progressive photoreceptor cell death, resulting in vision loss. Subsequently, inner retinal neurons develop aberrant synaptic activity, compounding visual impairment. In retinal ganglion cells, light responses driven by surviving photoreceptors are obscured by elevated levels of aberrant spiking activity. Here, we demonstrate in rd10 mice that targeting disruptive ...
متن کاملVisual function in myopia without central retinal degeneration.
Is there an additional loss of visual function in myopia beyond that attributable to refractive error and blur of the retinal image? Is there a component ofvisual loss caused by retinal changes? It is well known that in degenerative myopia, the pathological changes include retinal atrophy and may be associated with abnormalities of the electro-retinogram and dark adaptation.1 The paper by Manty...
متن کاملFeline central retinal degeneration.
Seven domestic cats with feline central retinal degeneration (FCRD) were investigated by ophthalmoscopy, fluorescein angiography, electroretinography, and light and electron microscopy. Little or no increase in lesion size was observed ophthalmoscopically over periods as long as four years. Five cats showed normal rod electroretinographic (ERG) responses and abnormal cone responses. In one cat ...
متن کاملUpregulation of Connexins 30 and 32 Gap Junctions in Rat Hippocampus at Transcription Level by Chronic Central Injection of Lipopolysaccharide
Background: Gap junctions composed of connexins (Cx) are functional in cell defense by propagation of toxic/death molecules to neighboring cells. Hippocampus, one of the brain regions with particular vulnerability to damage, has a wide network of gap junctions. Functional response of astrocytic Cx30 and neuronal Cx32 to hippocampal damage is unknown. Methods: We infused lipopolysaccharide (LPS)...
متن کاملIncreased phosphorylation of Cx36 gap junctions in the AII amacrine cells of RD retina
Retinal degeneration (RD) encompasses a family of diseases that lead to photoreceptor death and visual impairment. Visual decline due to photoreceptor cell loss is further compromised by emerging spontaneous hyperactivity in inner retinal cells. This aberrant activity acts as a barrier to signals from the remaining photoreceptors, hindering therapeutic strategies to restore light sensitivity in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2016
ISSN: 0014-4835
DOI: 10.1016/j.exer.2015.05.013